SCWTCA ENDOWMENT, INC. – SUPPORTING WHEATEN HEALTH RESEARCH AND EDUCATION


Wheaten Health Grants

Donor dogs may be need for the projects (check the project details) and, if you have a Wheaten diagnosed with any of the conditions being studied, please consider adding your Wheaten to study participation. The future health of our Wheatens is in your hands! Remember to update health information in your dogs' records in the SCWT Database http://scwtdb.org/.

2021 Grant #02428: Identifying Disease-defining Autoantibodies in Canine Addison’s Disease
2021 Grant #02534: Clinical Evaluation of Propranolol in Combination with Doxorubicin for the Treatment of Hemangiosarcoma
2021 Grant #02658: Characteristics of Sensory Neuronal and Muscle Pathology in Canine Degenerative Myelopathy to Identify Targets for Therapeutic Intervention
2018 AKC-CHF Grant #02519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations
  • Researchers: Edward B Breitschwerdt DVM, Matthew Breen PhD, North Carolina State University.
    Funding: $2,500 Funded by the SCWTCA Endowment.
    Research Update Reports September 2021
2012 Informative Family Project, Geriatric Dog Project contributing to AKC-CHF Grant 1485 Study of PLE/PLN (Protein-Losing Enteropathy/Nephropathy) in Soft-Coated Wheaten Terriers

Pelletizing DNA for Penn DNA Bank. Biopsies, shipping of samples, summer students, genetic testing DNA collection kits, AKC report fees for Penn on registration numbers, histopathology, testing expense and freezer expense. Summer students also helped with the Open Registry, with the collection of DNA samples, and acquiring medical records for phenotypic information for dogs with PLE/PLN, IBD, Addison’s disease, and renal dysplasia.

After years of research supported by hundreds of Wheatens and their owners and breeders, Meryl Littman VMD DACVIM and Paula Henthorn PhD at the University of Pennsylvania School of Veterinary Medicine (Penn Vet) identified mutations associated with PLN in two genes. A simple cheek swab test to determine an individual dog’s DNA status was introduced to Wheaten owners in May 2012.

Researcher: Meryl Littman VMD DACVIM, University of PA
Funding: $38,800. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

AKC-CHF Grant 1485 Study of PLE/PLN (Protein-Losing Enteropathy/Nephropathy) in Soft-Coated Wheaten Terriers

Researcher: Meryl P. Littman, VMD, DACVIM, University of Pennsylvania
Funding: $38,800. Approved by SCWTCA, Inc.; Funded by the SCWTCA Endowment, Inc.

Wheaten Health Surveys

July 2021 The SCWTCA Endowment, Inc. Survey • The Gulpies and Digestive issues in Wheatens

The Endowment created and conducted a survey on the Gulpies and Digestive issues in Wheatens with over 1,200 responses. See Gulpies Survey Results PDF here.

2019 Genetic Testing for PLN-Associated Variant Genes Follow Up Survey

University of Pennsylvania School of Veterinary Medicine, Paula Henthorn, PhD BS, Mariah Gentry DVM $5,000

Wheaten Health Webinars

08/16/2022 Wheaten Webinar • Degenerative Myelopathy

Presenter: Liz Hanson, DNA Research Information Specialist, University of Missouri College of Veterinary Medicine Genetics Lab

Sponsored By: SCWTCA, Inc & SCWTCA Endowment, Inc.

Liz will present her report from the St. Louis presentation on Degenerative Myelopathy. Please join us.

Questions? To be sure your questions are addressed, submit your questions beforehand to webinar@scwtca.org. Questions will also be taken at the conclusion of the Webinar.

Check back for ZOOM details and link to Webinar.

  • Link to ZOOM Details: Degenerative Myelopathy

05/17/2022 Wheaten Webinar • C-BARQ, The Canine Behavioral Assessment & Research Questionnaire

Presenter: James Serpell PhD Emeritus Professor of Animal Welfare, School of Veterinary Medicine University of Pennsylvania

Sponsored By: SCWTCA, Inc & SCWTCA Endowment, Inc.

C-BARQ is a standardized behavioral evaluation tool. This can be a reliable, validated method for measuring behavior problems in dogs.

You can sign up as pet owners and take the questionnaire on 1-3 of your dogs, if you like. You will need this six-digit code to access the account: 758847. There is no charge or fee for this as the SCWTCA Endowment Inc. has set up an account for us. The link is https://vetapps.vet.upenn.edu/cbarq/.

Click on "Sign Up Today" and create a brief profile. Next, enter a dog by clicking on "Add a Dog." Then, select "Dog is participating in a study" and click "Next". Select the name of your organization: "SCWTCA Endowment Inc." and provide this six-digit code: 758847. Complete the questionnaire on your dog(s). An analysis will be sent to you.

04/19/2022 Wheaten Webinar • The Unique Soft Coated Wheaten Terrier – Head/Ear Characteristics

Presenter: Cindy Vogels

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc.

Cindy is an AKC Judge and longtime member of the SCWTCA. She and her mother, Jackie Gottlieb, bred over 100 “Andover” SCWT Champions. She has judged “Best in Show” at Westminster KC and Montgomery County KC.

03/15/2022 Wheaten Webinar • Orthopedic Issues in Wheatens

Presenter: Darryl Millis MS DVM DACVS CCRP, Professor of Orthopedic Surgery, University of Tennessee at Chattanooga College of Veterinary Medicine

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc., SCWTCA Health Committee

02/15/2022 Wheaten Webinar • Optimum Age for Spay and Neuter

Presenter: Erin E. Runcan DVM DACT Assistant Professor of Theriogenology & Reproductive Medicine, The Ohio State University College of Veterinary Medicine

Sponsored By: SCWTCA, Inc & SCWTCA Endowment, Inc.

You may recall Dr. Runcan’s very informative session (June 2021) on managing a Stud Dog, “Let’s Hear It For The Boys!”

Tune in for this presentation to add to your understanding of this topic that is a significant piece of information to share with new Puppy Owners.

11/16/2021 Wheaten Webinar • PLN/Kidney Disease Update

Presenter: Meryl Littman VMD DACVIM

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc., SCWTCA Health Committee

10/26/2021 Wheaten Webinar • Ectopic Ureters/Urogenital Disorders in Wheatens

Presenter: Julie Byron DVM MS DACVIM; Professor, Clinical Small Animal Internal Medicine, Ohio State University — College of Veterinary Medicine

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc., SCWTCA Health Committee

09/21/2021 Wheaten Webinar • Temperament & Rage Syndrome

Presenter: Karen Overall MA VMD PhD DACVB; Editor in Chief, Journal of Veterinary Behavior — Clinical Applications and Research

Sponsored by: SCWTCA, Inc., SCWTCA Endowment, Inc. $350, SCWTCA Health Committee

08/17/2021 Wheaten Webinar • Microphthalmia — Inherited Eye Diseases in the SCWT

Presenter: Gustavo Aguirre VMD PhD PhD(hc), American College of Veterinary Ophthalmologists Professor of Medical Genetics and Ophthalmology, University of Pennsylvania School of Veterinary Medicine

Sponsored By: SCWTCA, Inc.

07/20/2021 Wheaten Webinar • CHIC, Genetic Tests, & Summertime Thoughts

Presenters: Susan Ratliffe, Beth Sorenson, Elaine Azerolo, Cyndi Stokvis, & Neil O’Sullivan

Sponsored By: SCWTCA Health Committee

05/18/2021 Wheaten Webinar • Gulpies, IBD, & Food Allergies
04/20/2021 Wheaten Webinar • Dawn of DNA Testing

Dawning of the age of DNA testing… where to test, what does it mean, and adding the information to the SCWT database

Presenter: Dr. Neil O’Sullivan, noted Geneticist and longtime Wheaten breeder

03/16/2021 Wheaten Webinar • Exploring the SCWT Database

Presenter: Anna Marzolino, Chair of the SCWTCA Endowment, Inc.

02/16/2021 Wheaten Webinar • Coat Color Genetics in Wheatens

Presenter: Dr. Neil O’Sullivan, noted geneticist and longtime Wheaten breeder

The first in the series, Coat Color Genetics in Wheatens was presented by longtime Wheaten breeder and noted geneticist Dr. Neil O’Sullivan. Neil joined the SCWTCA Board in January 2021 and brought the concept of a webinar series to reality in a matter of weeks. Announced with just a few days notice, nearly 80 people joined us live for the airing of this highly engaging talk with Neil.

Wheaten Health Projects

07/8/2022 — SCWT Early Intestinal Disease Marker Study

Wheaten Terriers diagnosed with PLE and healthy Wheaten Terriers are needed for a study with NC State University School of Veterinary Medicine. NCSU is beginning a study it hopes will identify SCWTs with PLE before there are any clinical bloodwork changes. Participation is specific: 8-10 “normal” Wheatens and 8-10 “affected” Wheatens are needed. Testing is done free of charge at NCSU in Raleigh, NC. There are financial incentives. For more information, contact Katie Tolbert DVM at mktolbe2@ncsu.edu.

Download the Client Consent Form PDF.

12/3/2021 — Wheaten Health Newsletter inaugural annual issue released!
2021 Annual Health Testing Protocols updated

Annual Health Testing Protocols have been updated and approved by Dr Littman. This PDF handout can be printed and given to your vet and kept in their file. This will ensure that you get all the proper health testing completed at the time of the visit and won't have to go for subsequent visits. As you can see, Dr. Littman has recommended that ALL Wheaten Terriers have the DNA Test for the PLN Variant Gene. She has listed the companies that have made the test available to the general public.

As someone in the SCWTCA Health Committee just stated, "A urinalysis is a Wheaten's best friend." A good thing to remember!

2020 Dr. Paula Henthorn's June SCWT PLE/PLN Research Progress Report

1. Survey
A 91-question survey was developed and distributed (in three phases) to owners and breeders, beginning early this year. A single survey was sent for each of 3773 dogs that had been tested using the PLN-Associated Variant Genes Test (and thus, we have DNA for these dogs). We have had 883 completed responses, of 1204 surveys that have been started, and we are still accepting completed surveys (until June 14th, with extensions possible if people email Dr. Gentry and ask for the extension). We are examining information provided from the surveys, with the first goal of identifying the dogs that will be most useful for our studies and obtaining medical records for these dogs. This first step is underway, with the help of a Penn undergraduate pre-vet student intern, who will be contacting veterinary clinics to obtain medical records.

2. Sequencing dogs for studies of both PLE and PLN
The Animal Health Trust in England has sequenced two dogs, including one healthy 13-year-old SCWT. Sequencing of 10 additional dogs has been completed, and the data files transferred to our laboratory. All 12 of these dogs will be useful for the study of PLE, with some of the dogs also useful for studies that may enhance genetic testing for PLN. The analysis will go into full swing when we can get access to the computer that we need for the analysis. (All non-essential research was suspended starting March 18th, and limited access to our laboratories is now being phased in.)

3. GWAS (Genome Wide Association Study, using SNP chips)
This phase is on hold until we identify additional dogs for GWAS analysis, based on information from steps 1 and 2 above.

4. Offer additional genetics tests for use by SCWT breeders: (DM/Degenerative Myelopathy) and Microphthalmia
Two genetic disease that have been identified in Wheaten Terriers are listed above. We have developed assays for these tests and now offer them through the PennGen laboratories. We have created two documents (one to announce the test availability, and one to explain the genetics of microphthalmia in SCWT, based on the study performed in Finland (Kaukonen et al. 2018 Cell Reports 23(9):2643-2652). To determine if this disease variant allele is present in the North American SCWT population, we tested 66 of the DNA samples derived from PLN testing. Fifteen percent (10 of 66 samples) tested as carriers for the disease-associated variant in the RPB4 gene. (Among these samples were 48 samples that were received after mid-November 2019. Five of these recent samples were carriers.) None of the 66 samples had two copies. This is a small sample size, but it does demonstrate that this disease-causing gene variant is present in the SCWT population. Genetic testing, particularly of any female that is being considered for breeding, will allow breeders to avoid affected puppies in their breeding programs.

Finances (by numbered activities above)
1. $15,500 was contributed from the SCWTCA and the SCWT Endowment ($7750 each) to cover salary for Dr. Mariah Gentry and for a student researcher. After Penn’s share of these gifts (note that the majority of these funds come to the School of Veterinary Medicine, thus indirectly supporting this work), $12,400 was available for our work. To date, $11,000 has be spent for Dr. Gentry’s salary. Dr. Gentry will be working on the project until the end of 2020. Funds needed in excess of $12,400 for Dr. Gentry and the student intern will be supplied from previous gifts to the project.
2. $10,000 was contributed from the SCWTCA and the SCWT Endowment ($5000 each) for ten dog genome sequences, with $8000 directly available for this project. The fee for sequencing 10 dogs was $8200, and less than originally quoted. Additional funds from previous donations be applied to the annual software fees for sequence and GWAS analysis software (annual fee of $3000).
3. The estimate of the cost for this part of the research was originally estimated at $10,000, although costs will be re-examined as the scope of the necessary work becomes clearer.
4. All costs for the development of the assays, and initial screening for microphthalmia were completely covered by the PennGen laboratories, including technician and faculty salaries.
[PennGen is a genetic testing facility operated through the Section of Clinical Genetics and Advanced Therapies (CGAT) at the University of Pennsylvania's School of Veterinary Medicine. It is a not-for-profit laboratory offering testing for genetic diseases, primarily in dogs and cats, and other molecular diagnostic services, such as somatic mutation screening in cancer patients. Together with CGAT’s Genetic Disease Discovery Laboratory, PennGen also engages in research to uncover the genetic basis of a wide range of diseases in animals and offers metabolic screening for inborn errors of metabolism including inherited and acquired forms of Fanconi Syndrome, and electron microscopy for ciliary dyskinesia in dogs.]

Respectfully submitted, with thanks for your ongoing support,
Paula Henthorn PhD, (Professor of Medical Genetics, University of Pennsylvania School of Veterinary Medicine)

2020 Genetic testing for Degenerative Myelopathy and Microphthalmia

The University of Pennsylvania's PennGen testing facility has announced the availability of genetic testing for DM and Microphthalmia, a condition involving eye abnormalities and blindness. Penn's research into PLN in Wheatens resulted in genetic testing for the variant alleles associated with risk of PLN and has been offering testing to owners since 2012. The Endowment, together with the entire Wheaten community, supported the research leading to the PLN testing. Owners can now obtain all three tests through PennGen. Read the PennGen announcement PDF at the PLN Testing Recommendations page.

2020 PLN Gene Testing – 2 vs 1

Testing for variant alleles associated with a risk for PLN ("DNA test) was initially developed at Penn based on Drs. Littman and Henthorn's research. That research showed that a DNA variant occurred in each of two genes, NPHS1 and KIRREL2, that are next to each other in their position on dog chromosome 1, and that the presence of these two variants on both copies of chromosome 1 indicated significantly increased risk for developing PLN (protein-losing nephropathy). In all Wheatens examined in the research study, these genes always showed the same patterns...

  • All dogs that were 1-1 for NPHS1 were also 1-1 for KIRREL2 (both copies each gene normal),
  • All dogs that were 1-2 for NPHS1 were also 1-2 for KIRREL2 (heterozygous for both genes),
  • All dogs that were 2-2 for NPHS1 were also 2-2 for KIRREL2 (both copies of each gene are variant).
In other words, the normal versions of these two genes were always inherited together, and the variant versions to these genes were always inherited together. Because of this it is not known with 100% certainly, which gene variant puts a dog at high risk for developing PLN, or whether or not they both act together (although, based on what is known about those two genes and proteins they encode, it is thought that NPHS1 is more likely).
Among the well over 4,000 Soft Coated Wheaten Terrier samples that Penn has analyzed since the test was introduced in 2012, there have been three (3) Wheaten terriers with results in which both genes had different genotypes, (for example 1-1 for NPHS1 and 1-2 for KIRREL2). In these cases, Penn reports the results more specifically, and discusses the ramifications of these results with the dog’s owner.
Penn's DNA testing continues to test both genes for two reasons. It is not 100% certain which of the two gene variants is most important in the PLN disease process and running two tests for each sample increases the quality control in the testing process. The websites of some commercial labs indicate that they only test for one of the genes, usually NPHS1.
2020 Ectopic Ureters
  • Researcher: Daniel Langlois BS DVM DACVIM, Michigan State University College of Veterinary Medicine
    Funding $1,600. Funded
2019 Whole Genome Sequencing (WGS), University of Pennsylvania
Since the introduction of the DNA test for PLN risk, owners and breeders have continued to hope for some similar testing for PLE. As noted, it is a more complex disease. WGS is an important component of this research.
WGS identifies essentially ALL of the DNA variants in an individual (there are millions of DNA variants within an individual mammal, compared to another member of the same species). The overall goal of WGS (combined with other information) is to identify all of the DNA variants in healthy and disease affected dogs, then to find which of those variants are associated with disease. This is done by analyzing the genome sequences by comparing to sequences of other dogs, examining genes known to be involved with the particular or similar diseases, such as inflammatory bowel diseases for PLE, and by performing GWAS (Genome Wide Association Studies with SNP chips) to point to the chromosomal regions that need to be studied. The goal of the proposed studies, combined together, is to further improve our ability to predict the occurrence of PLN. Dr. Henthorn has submitted 10 dogs for WGS sequencing to advance to our understanding of both PLE and PLN.
This sequencing information will make a significant contribution to our PLE research. Additional sequencing would build on that information, and it is particularly important to obtain sequence from PLE and normal geriatric dogs from the U.S. population. If we are very lucky, the WGS studies will immediately identify genes for further study. More likely, as implied above, we will need to do additional GWAS (genome-wide association studies) in the future.
In particular, Dr. Henthorn will compare genome sequences from affected and healthy geriatric dogs that are 2-2 (”2s” in the SCWT vernacular) to see if we can identify DNA changes that would allow us to more accurately predict the occurrence of PLN. An added benefit of the sequencing could find a dog(s) who have a variance for both PLE and PLN.
Penn Vet is collaborating with investigators at the Children’s Hospital of Philadelphia (CHOP), who study a form of IBD in very young children that appears similar to PLE in some SCWTs. If they find that the dogs have a similar genetic basis to their disease as do children, it opens the possibility of exciting collaborative work that could be mutually beneficial to dogs and kids.
We also want to sequence dogs affected with PLN and compare their genome sequences to healthy geriatric dogs (which will include the PLN 2-2 healthy geriatric dogs).
Researcher: Paula Henthorn.
Genome-Wide Association Study (GWAS) of Protein-Losing Nephropathy in Soft Coated Wheaten Terriers — Genetic Testing for PLN-Associated Variant Genes

University of Pennsylvania School of Veterinary Medicine, Paula Henthorn PhD BS Funding: $7,750

2016 Pilot Association Study of PLE/PLN in SCWTs
Nearly one hundred DNA samples, including both “affected” and “normal control” dogs, were chosen for initial analysis by the Section of Medical Genetics at the University of Pennsylvania School of Veterinary Medicine. These samples were subjected to a new technology that assays thousands of single-nucleotide polymorphisms (SNPs) simultaneously.
Within a single mammalian species (such as dogs or humans), there are millions of SNPs, and geneticists use them to find the locations of genes that cause various traits, including diseases. If the location can be determined, then it becomes possible (for a species that has had its genome sequence determined) to:
  • examine genes in that region as candidates for involvement in the disease process;
  • develop DNA-based genetic tests. While this sounds straight-forward in theory, it can be difficult to execute, particularly for a disease that is complex, as is PLE/PLN.
PLE/PLN does not appear to be simply inherited, and may be influenced by environmental factors, making it much more difficult to study.
We refer to our initial study as a pilot study because, due to the complexity of the disease, we cannot accurately predict how many dogs are actually needed to have a strong chance of success. In studies of complex genetic diseases in humans, tens of thousands of individuals are studied.
Funding: $9,000. Approved by SCWTCA, Inc.; Funded by the SCWTCA Endowment, Inc. and the Meryl P. Littman Wheaten Fund supported through the generosity of Dr. Littman’s clients and Wheaten friends.
2015 Freezer Storage
Purchase of a new freezer to store SCWT DNA samples.
University of Pennsylvania, School of Veterinary Medicine Trustees of the Univ. of PA School of Veterinary Medicine
Funding: $9,142
2014 Trustees of the University of Pennsylvania School of Veterinary Medicine SCWT Histopathology & Testing Expense
Funding: $5,000
2013 Purchase and Maintenance of Database
After a number of years in development, the SCWTCA Endowment, Inc. is excited to announce the launch of the Soft Coated Wheaten Terrier Database at http://www.scwtdb.org.

Funding: $7,600

2013 Tufts University Breeding & Genetics Conference
Attendee: Deb Van De Ven
Funding: $235. Approved by SCWTCA, Inc. Funded by SCWTCA Endowment, Inc.
2012 Genome-Wide Association Study (GWAS) of Protein-Losing Nephropathy (PLN) in Soft Coated Wheaten Terriers, Genetic Testing for PLN-Associated Variant Genes
After years of research supported by the owners and breeders of hundreds of Wheatens throughout the world, Dr. Meryl Littman and Dr. Paula Henthorn at the University of Pennsylvania School of Veterinary Medicine (Penn Vet) identified mutations associated with PLN in two genes.

Samples from the PennVet SCWT DNA Bank were used in a genome-wide association study (GWAS) using 177,000 single nucleotide polymorphisms (SNPs), of which 81,097 SNPs were informative. Control dogs (unaffected Wheatens aged 14 – 18) and affected dogs were studied, as were dogs of other breeds. PLN was found to be associated with changes in two genes responsible for encoding the proteins found in the podocyte slit diaphragm, a fundamental component of the glomerular filtration barrier in the kidney.

For more information, please see the Research Abstract as well as the peer-reviewed research report published in Mammalian Genome in January 2013.

The research resulted in a DNA cheek swab test, introduced to Wheaten owners in May 2012. DNA collection kits were made available worldwide at no cost to SCWT owners and breeders to assist Drs. Littman and Henthorn in gathering 1,000 SCWT DNA samples for a prevalence study between May and September 2012. The SCWTCA, Inc., the SCWTCA Endowment, Inc., and the Genetic Research Fund combined efforts financed this project.

After the introduction of the test in 2012, SCWTCA, the Endowment, and the Genetic Research Fund Boards, issued a Statement on Genetic Testing for PLN-Associated Variant Genes endorsing testing for PLN-associated variant genes by breeders and stud dog owners as one tool in the assessment of breeding stock.

Testing information and information guides can be found on the DNA testing page of The SCWT Club of America website.

In 2016, the membership of the SCWTCA voted to amend its Code of Ethics to require use of this test prior to breeding.

Researchers: Claire A. Wiley, Meryl P. Littman, Michael G. Raducha, Paula S. Henthorn, University of Pennsylvania School of Veterinary Medicine

2012 Student Researcher Professional Development Award

Claire Wiley
Grant: $560. Approved by SCWTCA, Inc. Funded by SCWTCA Endowment, Inc.

2009 AKC-CHF National Parent Club Health Conference

Various presenters addressing health issues applicable to most breeds.
Attendee: Jana Carraway

Funding: $200. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

2008 Rabies Challenge Charity Trust
Private fund supporting longitudinal work to address the duration of immunity conveyed by rabies vaccine with the intent of extending the legally required interval for rabies boosters to 5, then 7 years.
Researcher: Dr. Ronald Schultz, University of Wisconsin-Madison
Funding: $500. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

2007-2008 University of Missouri Canine Phenome Project
The purpose of the Canine Phenome Project: to establish a DNA bank with supporting data for use by researchers to identify the genes responsible for canine diseases and other characteristics. For Wheaten owners, an opportunity to store DNA from Wheatens for future use by researchers interested in finding the genetic cause of PLE, PLN, RD, Addison's, and/or other diseases. NIH Lifetime Study and Siblings Pair Study included.
  • CPP Participant Fee Sharing
    Paid 1/2 of the participant registration fee for 991 SCWTs whose blood was drawn during SCWTCA sponsored clinics to produce DNA samples for future Wheaten-related research.
    Researcher: Dr. Gary Johnson, University of Missouri - Columbia
  • CPP Blood Draw Clinics
    Paid 1/3 of the cost to help sponsor 21 blood draw clinics to acquire DNA samples for the CPP.
    Researcher: Dr. Gary Johnson, University of Missouri - Columbia
  • National Institutes of Health: Lifetime Study of the SCWT, 2007-2008
    Seven of the 21 blood draw clinics described above provided 103 samples for the NIH study.
    Researcher: Dr. Elaine Ostrander, Ostrander Canine Genomics Lab, Bethesda, MD
  • Sibling Pairs Study SNIP Chip Purchase, 2009
    Technology to compare 24 pairs of affected and non-affected SCWT siblings.
    Researcher: Dr. Gary Johnson, University of Missouri - Columbia
Funding: $25,966 (includes Blood Draw Clinics and SNIP Chip Purchase). Approved by SCWTCA, Inc.; Funded by the SCWTCA Endowment, Inc. and National Institute of Health, Ostrander Canine Genomics Lab Canine Phenome Project
2006 4th Annual CHF Canine Health Conference - Chicago, IL
  • Attendees Elaine Azerolo and Susan McGee. $5,000 Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.
2006 Investigation of Antigenic Causes of Vaccine-Associated Allergic Reactions in Dogs
  • Researcher: Dr. George Moore, Purdue University
2006 AKC-CHF Genetic Determinants of Malignant Melanoma
  • Researcher: Michael Kent DVM, UC Davis
    Funding: $1,000. Approved by SCWTCA, Inc; Funded by SCWTCA Endowment, Inc.
2003, 2004 Colony Dog Adopt a Colony Dog Fundraiser established
The Colony Dogs living at NC State University were used in numerous research grants to Dr. Shelly Vaden starting in 2003. This project was a coordinated fundraising campaign among individual and regional clubs to support the dogs’ daily care and well-being. Gifts were solicited by the Endowment and paid directly to NCSU Veterinary Medical Foundation.
Funding: $13,300. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment Colony Dog.; Expenses incurred by SCWTCA Endowment, Inc.

2002 & 2004, AKC-CHF Grant 2219 Longitudinal Clinical Study, Mode of Inheritance and Therapeutic Trial of PLE/PLN in Soft Coated Wheaten Terriers

From birth comparison of SCWTs fed hypoallergenic diet with SCWTs fed normal diet. AKC-CHF provided oversight for grant administration. SCWTCA matched funds for two prior related grants starting in 1996.
Researcher: Shelly Vaden DVM PhD DACVIM, North Carolina State University
$55,600 Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

Ongoing Fecal A1PI Kit Program
The kit was created to eliminate the owner’s cost of a vet submitting samples to the TAMU GI Lab and to insure the samples arrived frozen to the lab for accurate testing of intestinal protein loss. Distribution points set throughout the US & Canada.
The kit continues to be made available by the SCWTCA Endowment, Inc., at manufacturer’s cost.
Approved by SCWTCA, Inc.; Distributed by the SCWTCA Endowment, Inc.

2001 SCWTCA Endowment established
The Endowment had its origins in the 1995 establishment of the SCWTCA Health Fund. By 2001, the decision was made to create a separate non-profit which was incorporated in 2004 as the SCWTCA Endowment, Inc. The Endowment gained 501(c)3 status effective in 2004.